CelVivo
CelVivo
Publications
  1. Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors
    Krzysztof Wrzesinski and Stephen J. Fey
    Bioengineering, 5 (2) 1-25: 2018
    http://www.mdpi.com/2306-5354/5/1/22
    DOI: 10.3390/bioengineering5010022
    View Publication (PDF)
  2. Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective.
    Carlemi Calitz, Josias H. Hamman, Stephen J. Fey, Krzysztof Wrzesinski & Chrisna Gouws
    Toxicology Mechanisms and Methods, 2018
    https://doi.org/10.1080/15376516.2017.1422580
    DOI: 10.1080/15376516.2017.1422580
    View Publication (PDF)
  3. Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids.
    K. Wojdyla, K. Wrzesinski, J. Williamson, P. Roepstorff, S.J. Fey, A. Rogowska-Wrzesinska
    Toxicology Research 5(2) 905-920, 2016
    http://xlink.rsc.org/?doi=c5tx00469a 
    DOI: 10.1039/C5TX00469A
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  4. From 2D to 3D - a new dimension for modelling the effect of natural products on human tissue.
    K. Wrzesinski and S.J. Fey
    Current Pharmaceutical Design 21(38): 5605-5616, 2015.
    PMID: 26429710
    DOI: 10.2174/1381612821666151002114227
  5. Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns.
    A. Tvardovskiy, K. Wrzesinski, S. Sidoli, S.J. Fey, A. Rogowska-Wrzesinska, O.N. Jensen
    Molecular and Cellular Proteomics 14(12):3142-53; 2015.
    PMID: 26424599
    DOI: 10.1074/mcp.M115.048975
    Please write to info@celvivo.com for a pdf copy of this publication
  6. The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments.
    K. Wrzesinski, A. Rogowska-Wrzesinska, R. Kanlaya, K. Borkowski, V. Schwämmle, J. Daia, K.E. Joensen, K. Wojdyla, V. Botelho Carvalho & S.J. Fey
    PLOS One 9(9) 1-15; 2014
    PMID: 25222612
    DOI: 10.1371/journal.pone.0106973
    View Publication (PDF)
  7. The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments.
    K. Wrzesinski, A. Rogowska-Wrzesinska, K. Borkowski, V. Botelho Carvalho & S.J. Fey
    Poster at 9th Danish Conference on Biotechnology and Molecular Biology, Vejle; 2014
    DOI: 10.13140/2.1.2643.2965
  8. Heteromer score – using internal standards to assess the quality of proteomic data.
    A. Rogowska-Wrzesinska, K. Wrzesinski and S.J. Fey
    Proteomics. 14(9):1042-7 2014
    PMID: 24616253
    DOI: 10.1002/pmic.201300457
    Please write to info@celvivo.com for a pdf copy of this publication.
  9. Microgravity spheroids as a reliable, long term tool for predictive toxicology.
    S.J. Fey and K. Wrzesinski
    Toxicology Letters, 221S S153 2013.
    DOI: 10.1016/j.toxlet.2013.05.318
  10. Determination of acute lethal and chronic lethal dose thresholds of Valproic acid using 3D spheroids constructed from the immortal human hepatocyte cell line HepG2/C3A.
    S.J. Fey and K. Wrzesinski
    In ''Valproic Acid: Pharmacology, Mechanisms of Action and Clinical Implications'' Nova Science Publishers, New York. Ch. V, 141-165; 2013
  11. Human liver spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation.
    K. Wrzesinski, C.M. Magnone, L. Visby Hansen, M. Ehrhorn Kruse, T. Begauer, M. Bobadilla, M. Gubler, J. Mizrahi, C. Møller Andreasen, K. Zhang, K. Eyed Joensen, S.M. Andersen and S.J. Fey
    Toxicology Research; 2(3) 163-172; 2013
    DOI: 10.1039/C3TX20086H
    NB: Manuscript featured on the front cover of the journal.
    View Publication (PDF)
  12. After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver.
    K. Wrzesinski and S.J. Fey
    Toxicology Research; 2(2) 123-135; 2013
    DOI: 10.1039/C2TX20060K
    NB: Manuscript featured on the front cover of the journal.
    View Publication (PDF)
  13. Determination of drug toxicity using 3D spheroids constructed from immortalized human hepatocytes.
    S.J. Fey and K. Wrzesinski
    Toxicological Sciences 127(2) 403-411; 2012.
    PMID: 22454432
    DOI: 10.1093/toxsci/kfs122
    View Publication (PDF)


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