CelVivo
CelVivo
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June 2019

CelVivo #StressFree3D system used for 3 papers read at CellFit 3rd Annual Meeting. Thank you to Chrisna Gouws, Helle Frandsen, Bojana Zegura. See our LinkedIn post.


June 2019

#StressFree3D re-shared a post from I&L Biosystems GmbH. “From proliferative (2D) to functional (3D) stage. BioArray Matrix Drive unit enables the cultivation of spheroids in a 3D cell culture environment. The drive's control board fits into a standard CO2 incubator and has 16 independently control drive axles which can rotate in either direction at speeds from 1 to 60 rpm. The operation of the BioArray Matrix Drive unit is user-friendly by means of a tablet.
#Cellculture #Tissueengineering #3Dcellculture Read their LinkedIn post.


June 2019

We have joined the South African Biomedical Research & Innovation Platform at Advanced Cell Culture Collaborative Meeting in Cape Town. We are looking forward to expanding our collaboration in SA.

CelVivo

May 2019

At NIH Spring Biomedical Research Equipment and Supplies Tent Show! together with Bob Luton See our LinkedIn post.


May 2019

We have joined Competence Centre hashtag#TEDD.hashtag#StressFree3D

New from @TEDD Competence Centre Community in May with Partner Highlights company CelVivo IVS with Krzysztof Wrzesinski and Stephen Fey

See our LinkedIn post.


May 2019

At #esact meeting “Cell culture technologies: bridging academia and industry to provide solutions for patients” hashtag#stressfree3d hashtag#3dcellculture

ESACT meeting, May 5–8, 2019 in Copenhagen, Denmark. The theme of the conference will be “Cell culture technologies: bridging academia and industry to provide solutions for patients”. See our LinkedIn post.


May 2019

At the Danish Stem Cell Society hashtag#dascs meeting in Vejle.

See our LinkedIn post.


April 2019

We have visited Patrick Kugelmeier and discussed a joined venture into the hashtag#3Dcellculture projects. Looking forward to putting hashtag#sphericalplate5D and hashtag#StressFree3D systems to work together.

See our LinkedIn post.


February 2019

We are at the SMi’s 3rd Annual Conference "3D Cell Culture" February 20-21, 2019 | London, United Kingdom. hashtag#StressFree3D.

See our LinkedIn post.


February 2019

#StressFree3D

“Building the Liver” We have been sharing our knowledge and experience in #tissueengineering and #3dcellculture with 20 students from USA and Canada that are studying in Scandinavia via Danish Institute for Study Abroad (DIS).

Thank you #Jeanette Erbo Wern for nurturing the collaboration!

See our LinkedIn post.


February 2019

3D Medical conference, Maastricht, The Netherlands. Big thanks to all our customers and future customers for feedback and support!

See our LinkedIn post.


#StressFree3D system based toxicology

HepG2/C3A spheroids created using #StressFree3D system respond to drugs in much more physiological way compared to the same cells or even primary human hepatocytes grown in traditional 2D conditions.

Metformin, APAP, Amiodarone, Phenformin, Valproic acid

More details about this study here.

CelVivo

#StressFree3D spheroids are uniform in shape and size

and reach full functionality after 21 days. Spheroids can be maintained for up to one year, which allows for long term drug exposures and toxicity testing.

Watch them grow!


May 2018

CelVivo #StressFree3D is a next generation 3D omnigravital spheroid cell culture system. See our LinkedIn post.


May 2018

Two new #StressFree3D systems installed at Prof. Chrisna Gouw's group at North-West University (Potchefstroom Campus) in South Africa.

It is a pleasure to see happy customers Prof Chrisna Gouws and PhD Carlemi Calitz.

See our LinkedIn post.


May 2018

This week we are in South Africa, Potchefstroom installing two of our Stress Free 3D systems! See our LinkedIn post.


May 2018

#StressFree3D gives you precision reproducibility. Our patented bioreactor vessels provide key features for successful spheroid culture. See our LinkedIn post.


May 2018

CelVivo #StressFree3D has been used to grow over a dozen different cell lines, as well as other spheroid structures. See the full list on our LinkedIn post.


March 2018

CelVivo #StressFree3D and human hepatocytes have been used to study the oxidative stress induced by application of a therapeutic dose of APAP. Get the publisher's downloable PDF from our LinkedIn post.


February 2018

CelVivo CSO is Plenary Speaker at 12th World Congress on Pharmaceutical Sciences and Innovations in Pharma Industry CelVivo's CSO, Dr. Krzysztof Wrzesinski, delivered the plenary speech at the 12th World Congress on Pharmaceutical Sciences and Innovations in Pharma Industry, (February 26- 27, 2018 London). Attendees from over 70 companies and institutions heard speakers discuss newest approaches used for drug discovery and development, as well as strategies for creation of new drugs based on natural medicine compounds. Dr. Wrzesinski’s talk was entitled "Active 3D environment: a key to stable, reproducible, mimetic tissues". The talk presented advantages of using active 3D spheroid/organoid cultures for drug candidate screening.

Dr. Wrzesinski was honoured to be the judge of the conference young scientist poster session. The conference poster prize was awarded to PhD student Valeria Chiaula representing Danish Polymer Centre, Danish Technical University, Copenhagen, for her poster "Advanced wound care adhesives with new functional properties"- congratulation to Valeria.

See our LinkedIn post.


February 2018

CelVivo #StressFree3D was installed at the Department of Biomaterials, Institute of Clinical Dentistry in Oslo, Norway.
See our LinkedIn post.


November 2017

CelVivo's BioArray Matrix drive achieves 'CE marking' status
The term CE marking on a product is a manufacturer's declaration that the product complies with all the essential requirements of the relevant European health, safety and environmental protection legislation ('European Standards' or 'Harmonization Documents').

"This is a milestone achievement for us" says CEO Dr. Stephen Fey. "This will allow us to distribute our equipment freely within the EU, EFTA and EEA countries. It is a strong signal that our BioArray Matrix is a reliable and powerful new instrument for the 3D cell culture laboratory, and brings an exciting future to us and our collaborators."


May 2017

Citation Milestone
The founding manuscript "Determination of Drug Toxicity Using 3D Spheroids Constructed From an Immortal Human Hepatocyte Cell Line" has now been cited 48 times according to the Web of Science.

Link to manuscript:
https://doi.org/10.1093/toxsci/kfs122

Link to list of citing manuscripts:
http://apps.webofknowledge.com/InboundService.do?product=WOS&Func=Frame&DestFail=http%3A%2F%2Fwww.webofknowledge.com&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&SID=T2A1y2IlPxq9e6BNfMH&mode=CitingArticles&customersID=LinksAMR&IsProductCode=Yes&Init=Yes&viewType=summary&action=search&UT=WOS%3A000304198400009


April 2017

Completion of Innobooster Development Project
CelVivo has reported the successful, on time, completion of the Innobooster development project to the Danish Innovation Fund. The BioArray Matrix drive met all design specifications. The unit now logs all user entries and its own performance and makes this data available as documentation of operation performance (needed for example for Regulatory Authorities).


March 2017

Cell Guidance and Fitness
CelVivo's CSO, Dr. Krzysztof Wrzesinski, has been selected as a Danish representative for the managing committee of the COST Action “In vitro 3-D total cell guidance and fitness” (CellFit) CA16119. This is a European Union funded network aimed at developing tools to exploit environmental cues, mechano-transduction and 3D culture to stably maintain or address cells towards a specific fate. The goal of this network is to reduce the discrepancy between data obtained in vitro and in vivo by refining our present understanding of the cell environment, in order to create reliable in vitro models that may replace/reduce the use of animals.

The kick off meeting of the CellFit COST action was held in Brussels, Belgium on 16 March 2017. Dr. Wrzesinski was one of the 60 persons from 31 European countries represented.

More details about the CellFit COST action activities can be found under following links:

http://www.cost.eu/COST_Actions/ca/CA16119?management

https://www.facebook.com/COST-Action-16119-CellFit-1660173010901682/

http://www.nature.com/natureevents/science/events/55683-In_vitro_3_D_total_cell_guidance_and_fitness_CellFit


March 2017

BioArray Matrix System Upgrade
The BioArray Matrix (BAM) systems operating at the Centre of Excellence for Pharmaceutical Sciences, North-West University; Potchefstroom South Africa and at Diabetes Discovery Platform; South African Medical Research Council; Cape Town have been upgraded to BAM system version 4.6 which include active data logging system. Prof. Hamman, Dir Johan Louw and their groups acted as independent β-test sites for the new BAM drive.


January 2017

Parliamentary Presentation
Antibiotic resistance is an increasing menace facing our society. This is not only true for a country like Denmark where pig farming is an important export, but also to countries where the population is at risk from tuberculosis or any country that relies on antibiotics.

CelVivo's CEO, Stephen J. Fey was co-organiser of the open symposium "New Possibilities for Treatment of Multiresistant Infections with Non-antibiotics” which was held in the historical "Fællessalen" at Christiansborg – the seat of the Danish Parliament. The meeting was hosted by Jane Heitmann (Health spokesperson for Venstre) and Flemming Møller (MP) and moderated by Peter Hyldgård (Journalist, Videnskab.dk). Dr. Fey gave the presentation "Breaking resistance development using molecules 'dancing' in Fibronacci patterns" and described the opportunity to test toxicity of non-antibiotics in human mimetic systems.


November 2016

Danish Innovation Fund
The Danish Innovation Fund has awarded CelVivo Innobooster support to further develop its proprietary BioArray Matrix (BAM) drive. The developments will extend the performance of the BAM drive, captures and logs additional performance data and make it available to the user.


October 2016

EMBO Symposium on Organoids
CelVivo was well represented at the recent highly successful EMBO | EMBL Symposium "Organoids – Modelling Organ Development and Disease in 3D Culture" (Heidelberg, Germany (12-15 October 2016).

CelVivo's CSO, Dr. Krzysztof Wrzesinski presented a poster and a flash presentation "Mimicking the feeding-fasting cycle using microgravity 3D spheroids"

CelVivo's CEO, Dr. Stephen J. Fey presented a poster entitled "Epigenetic Markers and Histone Clipping are Reproduced in Microgravity 3D Spheroids". Both sets of data were obtained using the bioreactors and BioArray Matrix drive from CelVivo.


April 2016

Natural Products Chemistry to Drug Discovery
CelVivo's CEO, Dr. Stephen J. Fey is a Danish representative for participating in the CMST COST Action CM1407 "Challenging organic syntheses inspired by nature – from natural products chemistry to drug discovery".

The utility of the 3D cell culture in the BioArray Matrix drive system was illustrated at the second meeting of the CM1407, held in Madrid from the 3rd to the 6th April in a presentation entitled: "Active 3D spheroids recapitulate epigenetic marking and can be used to reveal novel signaling pathways".

http://www.cost.eu/COST_Actions/cmst/CM1407


March 2016

Toxicological and Efficacy Studies
CelVivo's CEO, Dr. Stephen J. Fey is a Danish representative for participating in the CMST COST Action CM1407 “Challenging organic syntheses inspired by nature – from natural products chemistry to drug discovery”.

CelVivo's BAM system was potential for toxicological and efficacy studies was described during the 3rd meeting of CM1407, held in Krakow, Poland from the 1st – 4th March in a presentation entitled “Testing natural products using an in-vivo-mimetic system”.



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