CelVivo
CelVivo
Publications
  1. A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model
    Carlemi Calitz, Josias H. Hamman, Stephen J. Fey, Alvaro M. Viljoen, Chrisna Gouws and Wrzesinski K.
    Journal of Ethnopharmacology 239:111897. E-pub April 19, 2019
    https://doi.org/10.1016/j.jep.2019.111897
    DOI: 10.1016/j.jep.2019.111897
    Please write to [email protected] for a pdf copy of this publication
  2. Toxicity and anti-prolific properties of Xysmalobium undulatum water extract during short-term exposure to two-dimensional and three-dimensional spheroid cell cultures
    Carlemi Calitz, Josias H. Hamman, Alvaro M. Viljoen, Stephen J. Fey, Chrisna Gouws and Wrzesinski K.
    Toxicology Mechanisms and Methods 28-9, 641-652, 2018
    https://doi.org/10.1080/15376516.2018.1485805
    DOI: 10.1080/15376516.2018.1485805
    Please write to [email protected] for a pdf copy of this publication
  3. Metabolic Reprogramming and the Recovery of Physiological Functionality in 3D Cultures in Micro-Bioreactors
    Krzysztof Wrzesinski and Stephen J. Fey
    Bioengineering, 5 (2) 1-25: 2018
    http://www.mdpi.com/2306-5354/5/1/22
    DOI: 10.3390/bioengineering5010022
    View Publication (PDF)
  4. Recent advances in three-dimensional cell culturing to assess liver function and dysfunction: from a drug biotransformation and toxicity perspective.
    Carlemi Calitz, Josias H. Hamman, Stephen J. Fey, Krzysztof Wrzesinski & Chrisna Gouws
    Toxicology Mechanisms and Methods, 2018
    https://doi.org/10.1080/15376516.2017.1422580
    DOI: 10.1080/15376516.2017.1422580
    View Publication (PDF)
  5. Tissue-mimetic 3D cultures can determine the commercial potential of natural products and their derivatives.
    Krzysztof Wrzesinski and Stephen J. Fey
    Biomed Biopharm Res. (14) 2 Supl. 271, 2017
    https://doi.org/10.19277/bbr.14.2.168
    DOI: 10.19277/bbr.14.2.168
    Please write to [email protected] for a pdf copy of this publication
  6. Cell-free DNA in a three-dimensional spheroid cell culture model: A preliminary study.
    Janine Aucamp, Carlemi Calitz, Abel J. Bronkhorst, Krzysztof Wrzesinski, Josias H Hamman, Chrisna Gouws, Pieter J. Pretorius
    Int J Biochem Cell Biol. Aug; 89:182-192. Epub 2017 Jun 24, 2017
    https://doi.org/10.1016/j.biocel.2017.06.014
    DOI: 10.1016/j.biocel.2017.06.014
    Please write to [email protected] for a pdf copy of this publication
  7. Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids.
    K. Wojdyla, K. Wrzesinski, J. Williamson, P. Roepstorff, S.J. Fey, A. Rogowska-Wrzesinska
    Toxicology Research 5(2) 905-920, 2016
    http://xlink.rsc.org/?doi=c5tx00469a 
    DOI: 10.1039/C5TX00469A
    View Publication (PDF)
  8. From 2D to 3D - a new dimension for modelling the effect of natural products on human tissue.
    K. Wrzesinski and S.J. Fey
    Current Pharmaceutical Design 21(38): 5605-5616, 2015.
    PMID: 26429710
    DOI: 10.2174/1381612821666151002114227
  9. Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns.
    A. Tvardovskiy, K. Wrzesinski, S. Sidoli, S.J. Fey, A. Rogowska-Wrzesinska, O.N. Jensen
    Molecular and Cellular Proteomics 14(12):3142-53; 2015.
    PMID: 26424599
    DOI: 10.1074/mcp.M115.048975
    Please write to [email protected] for a pdf copy of this publication
  10. The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments.
    K. Wrzesinski, A. Rogowska-Wrzesinska, R. Kanlaya, K. Borkowski, V. Schwämmle, J. Daia, K.E. Joensen, K. Wojdyla, V. Botelho Carvalho & S.J. Fey
    PLOS One 9(9) 1-15; 2014
    PMID: 25222612
    DOI: 10.1371/journal.pone.0106973
    View Publication (PDF)
  11. The cultural divide: exponential growth in classical 2D and metabolic equilibrium in 3D environments.
    K. Wrzesinski, A. Rogowska-Wrzesinska, K. Borkowski, V. Botelho Carvalho & S.J. Fey
    Poster at 9th Danish Conference on Biotechnology and Molecular Biology, Vejle; 2014
    DOI: 10.13140/2.1.2643.2965
  12. Heteromer score – using internal standards to assess the quality of proteomic data.
    A. Rogowska-Wrzesinska, K. Wrzesinski and S.J. Fey
    Proteomics. 14(9):1042-7 2014
    PMID: 24616253
    DOI: 10.1002/pmic.201300457
    Please write to [email protected] for a pdf copy of this publication.
  13. Microgravity spheroids as a reliable, long term tool for predictive toxicology.
    S.J. Fey and K. Wrzesinski
    Toxicology Letters, 221S S153 2013.
    DOI: 10.1016/j.toxlet.2013.05.318
  14. Determination of acute lethal and chronic lethal dose thresholds of Valproic acid using 3D spheroids constructed from the immortal human hepatocyte cell line HepG2/C3A.
    S.J. Fey and K. Wrzesinski
    In ''Valproic Acid: Pharmacology, Mechanisms of Action and Clinical Implications'' Nova Science Publishers, New York. Ch. V, 141-165; 2013
  15. Human liver spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation.
    K. Wrzesinski, C.M. Magnone, L. Visby Hansen, M. Ehrhorn Kruse, T. Begauer, M. Bobadilla, M. Gubler, J. Mizrahi, C. Møller Andreasen, K. Zhang, K. Eyed Joensen, S.M. Andersen and S.J. Fey
    Toxicology Research; 2(3) 163-172; 2013
    DOI: 10.1039/C3TX20086H
    NB: Manuscript featured on the front cover of the journal.
    View Publication (PDF)
  16. After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver.
    K. Wrzesinski and S.J. Fey
    Toxicology Research; 2(2) 123-135; 2013
    DOI: 10.1039/C2TX20060K
    NB: Manuscript featured on the front cover of the journal.
    View Publication (PDF)
  17. Determination of drug toxicity using 3D spheroids constructed from immortalized human hepatocytes.
    S.J. Fey and K. Wrzesinski
    Toxicological Sciences 127(2) 403-411; 2012.
    PMID: 22454432
    DOI: 10.1093/toxsci/kfs122
    View Publication (PDF)


CelVivo
 
Contact
+45 5117 7227
Email Us
Address:
CelVivo IVS
Middelfartvej 469
DK-5491 Blommenslyst, Denmark
Connect
LinkedInTwitter
Newsletter
CelVivo
Copyright © 2016, All rights reserved.
Designed by: Hawthorne Software Engineering