3D CELL CULTURE TECHNOLOGY
Mimicking in vivo performance
Grow your cells using CelVivo’s 3D cell culture technology
to generate in vitro models that closely resemble real-world conditions.
New ClinoStar publications
Blastoids mimic IVF-derived blastocysts when grown in a 3D environment.
See this breakthrough publication, which holds great potential to advance animal agriculture by providing an accessible in vitro blastoid model for studying bovine embryogenesis.
Omicron BA.5 infects human brain organoids
COVID-19 has affected human brain organoids. See this publication about how some BA.5 infected patients are experiencing increased loss of the sense of smell (anosmia).
Pushing the frontiers of in vitro models
In close collaboration with scientists, CelVivo aims to innovate 3D cell culture research, pushing the frontiers of in vitro models by solving the bias of active diffusion and no sheer stress.
This means that cells can present a physiological performance similar to what is seen in vivo and the re-establishment of intercellular communication, whether they are spheroids, organoids, or other aggregates.
Watch how the ClinoStar works
The ClinoStar 3D cell culture technology is made for scientists that cultivate and mature cells.
The technology can be used across several application areas and allows the generation of uniform, reproducible and functional spheroids, and organoids. These spheroids mimic the function, structure, and architecture of in vivo cells. The technology thus lets you perform research using cell models with an unprecedented correlation between in vivo and in vitro conditions and closes the gap between 2D cell culture and cell function.
See how it works on the application areas below.
Read new publications about how blastoids grown in a 3D cell culture environment can create in vitro models of blastocysts.
Watch exclusive webinars and interviews about how other scientists work with long-term liver cell cultures in the ClinoStar system.
See how other scientists have used the ClinoStar system for growing brain organoids in a 3D environment and how to get started yourself.
The CelVivo Technology
The ClinoStar technology is developed to mimic in vivo performance with low sheer stress, allowing scientists to generate in vitro models that closely resemble real-world conditions. Thus, creating more accurate, reproducible research and experiments – without animal use.
Doc. Assistant Center for Oncological Research, University of Antwerpen
“Expanding Organoids for drug screening has always been a time-consuming and labor-intensive process.
We are astonished by how much faster organoids grow in the ClinoStar and by the ease of use for maintaining long-term cultures”.
Professor Stine Falsing Pedersen
Department of Biology, University of Copenhagen
“Organoids derived from murine cancer models or patient tumors are valuable tools for precision medicine and drug development, however, the standard culture method is expensive, time-consuming and low-throughput.
We use the CelVivo ClinoStar system to grow spheroids and organoids”.
Marcus Krüger, Dr. rer. Nat.
Otto Von Guericke University, Magdeburg
“With the new ClinoStar, we are able to maintain long-term 3D cell cultures that are used not only for tissue engineering approaches but also to study the complex processes that allow cancer cells to survive as a metastasis.
This is critical for exploring new therapies to destroy cancer cells with metastatic properties”.
Professor Madhu Dhar
College of Veterinary Medicine, The University of Tennessee Knoxville
“We are using the ClinoStar to culture primary neurospheres with the goal of adding endothelial and mesenchymal stromal cells to produce neural organoids for in vivo application in the regeneration and repair of peripheral nerve injuries”.
Professor Jay Gopalakrishnan
Institute of Human Genetics, Heinrich Heine Universität, Düsseldorf
“Our laboratory is known for dissecting principles of human brain development and decoding disease mechanisms using iPSC-derived brain organoids.
With the ClinoStar, we have been able to generate human brain organoids in a reproducible, easy, and abundant manner with relatively less effort”.
Start your journey with the ClinoStar today. Download our product brochure to see all the details about how to work with the ClinoStar, ClinoReactors, and the control unit.
Cell Culture History
Cell culture basically consists of providing cells isolated from an organism with conditions to keep them alive and make them proliferate. Initially, this was done by growing the cells on flat surfaces (2D) but with the realization that their performance is limited, the focus has now shifted to growing them as clusters (organoids or spheroids) where they more closely mimic what occurs in vivo.
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