The most user-friendly system for working with organoids yet
Next-level organoids made easier than ever
The ClinoStar 2 from Celvivo enables you to culture cells in 3D with low shear forces, reduced depletion zones, and reproducibility.
It mimics in vivo functionality and allows you to monitor and control your cells remotely from anywhere in the world. All this and more in a stand-alone system anyone can learn to use.
Features
- Each reactor has an associated motor that can spin the reactor slowly. The speed of the motor can be precisely controlled individually using Celvivo’s cloud solution.
- A fan is installed in the chamber for ventilation purposes to ensure a uniform environment within the chamber.
- For decontamination, a UV-C beacon is placed in the chamber.
- 6 individual cameras allow monitoring of each bioreactor in real-time.
- The door has a push-to-open mechanism allowing the user to open the door with the elbow, so the hands of the user can be used for holding bioreactors.
- The unit has a small footprint and can be stacked up to 3 units high.
The all-in-one bioreactor
The ClinoReactor (patent pending) is an all-in-one bioreactor. The front wall of the chamber is also a lid that can be clicked on and off, thus giving full access to the chamber in a petri-dish manner. Perfect for sampling and great for adding and removing large constructs.
The vents on top of the ClinoReactor ensure a constant airflow over the membrane, allowing CO₂ to be in equilibrium with the media inside the cell chamber.
The ClinoReactor has a humidification system for minimizing the risks of infections and keeping the volume constant in the incubation chamber.
Features
- Advanced bioreactor which allows you to culture cells as spheroids
- Comes single wrapped
- Has a 10 mL growth culture chamber
- The humidification system consisting of water beads ensure constant volume of media.
- A semi-permeable membrane ensure that growth media is in equilibrium with the CO₂ content in the incubator
- The transparent front lid can be removed giving access to a petri-dish like cell culture chamber
- Access ports together with the stand-up function allow easy exchange of media
- The front port allows easy sampling of spheroids
Accurate oxygen levels
It’s crucial to accurately establish and monitor oxygen levels during the culture period to mimic in vivo physiological conditions of tissues or organs.
Oxygen concentrations in the human body vary, ranging from around 12% in the lungs to 5% in the brain, and can be as low as 0.1% in tumor tissues. The ClinoStar hypoxia unit is an add-on module that enables the manipulation of in vitro atmospheric composition to tailor it to the specific physiological needs of tissues or organs.
Features
- Ability to regulate the level of oxygen from atmospheric to 2%
- Rapid attainment of the set point for the media’s oxygen level is achieved through active gas exchange between the ClinoStar and the ClinoReactor humidification chamber.
- The ClinoReactor’s semi-closed environment temporarily preserves hypoxic conditions for operations within a regular atmospheric oxygen environment (21%). This simplifies short-term handling procedures, such as microscopy observation and documentation.
Control your constructs from anywhere
The ClinoStar is controlled using the software CelVivo Cloud. CelVivo Cloud can be accessed remotely from any internet-enabled device.
This means you can control your ClinoStars from anywhere. The software allows you to adjust environmental conditions (CO₂, O₂, temperature) for each ClinoStar unit. You can also adjust the speed of each bioreactor from 1 to 100 rpm in 0.1 rpm steps (clockwise or anticlockwise).
Features
- Access your ClinoStar through multiple devices from anywhere.
- Monitor your cultures and adjust individual rotational speeds as they progress.
- Keep a register of changes and updates through the event log.
- Automatic UV-C decontamination cycles can be remotely initiated.
- Give team members individual control over certain ClinoStars.
Watch how to work with our system
Want to know more?
We’re always happy to help if you want to know more about how your research can benefit from our solutions or if you have any questions regarding our products.
Let us know your main research area of interest and what you want to know.
We will make sure that one of our specialists will reach out to you.
Start growing next-level organoids today
